In theory, just the removal of oil squirters could increase engine knock with lower octane fuel. However, I don't know how significant of a role they play. Unfortunately, almost all 426s I have seen have opted to remove them due to interference. The CP Carillo pistons have additional oilers to keep the wrist pin lubricated. I also don't see the same oil pressure as the factory 6.2L. Fully warmed up at idle, I'm seeing around 60psi with 75-80psi on cold starts and cruising.
I plan on running E85 the majority of the time. 93 pump gas will mainly be used to occasionally clean out the fuel system, during the wintertime, and when traveling out of state.